Native Thrombopoietin: Structure and Function
نویسندگان
چکیده
منابع مشابه
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متن کاملThrombopoietin.
By Shirley Ebbe I T HAS BEEN CLEAR for almost 20 years that platelet production is subject to homeostatic regulatory mechanisms that result in stimulation when the platelet count is li w’ and suppression when it is high.2 In spite of elapsed time, the physiologic processes that are involved in those regulatory mechanisms are not clear. Thrombocytopoiesis may be regulated by a humoral thrombopoi...
متن کاملThe biology of thrombopoietin and thrombopoietin receptor agonists.
Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. There is no "sensor" of the platelet count; rather TPO is produced in the liver at a constant rate and cleared by TPO receptors on platelets. TPO levels are inversely proportional to the rate...
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ژورنال
عنوان ژورنال: Stem Cells
سال: 1998
ISSN: 1066-5099,1549-4918
DOI: 10.1002/stem.160322